Protein Details: G protein-activated inward rectifier potassium channel 4

Protein ID

ICDB_Pro_0554

Protein Name

G protein-activated inward rectifier potassium channel 4

Gene Name

KCNJ5; GIRK4

Organism

Homo sapiens (Human)

Length

419 amino acids

AlphaFoldDB

AF-P48544-F1-model_v4.pdb

Function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium

Sequence

MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Hyperaldosteronism;Familial;Type Iii and Long Qt Syndrome

Location

Islets; exocrine pancreas and heart. Expressed in the adrenal cortex; particularly the zona glomerulosa.

DOI ID

10.1038/370456a0; 10.1038/378792a0; 10.1523/jneurosci.16-03-00930.1996; 10.1016/s0898-6568(99)00059-5; 10.1038/ng1285; 10.1038/nature04632; 10.1101/gr.2596504; 10.1126/science.1198785; 10.1016/j.ajhg.2010.04.017; 10.1210/en.2011-1733; 10.1161/hypertensionaha.111.183996; 10.1161/hypertensionaha.111.186478; 10.1210/jc.2012-1334; 10.1371/journal.pone.0041926; 10.1073/pnas.1121407109; 10.1210/jc.2013-2428; 10.1111/cen.13132; 10.1530/jme-15-0324

RefSeq

NP_000881.3; XP_011541111.1; XP_011541112.1